NFL Week 16 picks, predictions: New York Giants vs. Indianapolis Colts | Will Eli Manning, Saquon Barkley play spoiler?

The Giants were officially eliminated from NFL playoff contention, for the sixth time in the last seven seasons, following last week’s 17-0 loss to the Tennessee Titans, but can play spoiler on Sunday against quarterback Andrew Luck and the Indianapolis Colts. 

“I want to see good football and I want to win the game,” Giants head coach Pat Shurmur said this week, when asked how he’d handle the final two games of the season. “And I think that’s what we’re trying to get done.”

Entering Sunday at 5-9, Shurmur plans to start Eli Manning at quarterback and continue to utilize rookie running back Saquon Barkley the same as he has all season, as the 8-6 Colts remain alive for an AFC Wild Card berth. 

Here’s a look at NJ.com’s NFL staff picks for Sunday’s game, as well as a collection of predictions from national reporters and analysts: 

Even if the Giants are able to pressure Luck — which is unlikely, given the fact that the Giants enter with the league’s 30th ranked sack total — the Colts still have a dynamic running back duo with Marlon Mack and Nyheim Hines, who are both capable of replicating the Titans’ success on the ground utilizing Derrick Henry as a battering ram to the tune of 170 yards and two scores last week. Indianapolis has plenty more to play for, and the Giants could be without both wide receivers Odell Beckham Jr. and Sterling Shepard on Sunday. If you still have last-minute Christmas shopping to do, that might be a better investment of your day … 

The Pick: 

Colts 37, Giants 7

The Giants and Colts were competing for the No. 2 pick in the NFL Draft at this time last year. A year later, the Giants are playoff-less again while the Colts have eight wins. Why? The Colts got their offensive line in order and Andrew Luck is still at the top of his game. 

The Pick: 

Colts 24, Giants 13